The publications listed below exemplify the range and quality of research conducted by CVR members over recent years. An expanded bibliography is provided within the individual research groups section and a comprehensive bibliography may be obtained by entering the surname and initials (eg. Khachigian-LM) of an individual CVR group leader as a search term in the online Medline database.

Selected Publications 1999 -2003:

Holmes M, Turner J, Fox A, Chisholm O, Crossley M, Chong BH (1999).
hFOG-2: a novel zinc finger protein binds the co-repressor mCtBP2 and modulates GATA-mediated activation. J Biol Chem 274: 23491-8.

Hulett MD, Freeman C., Hamdorf BJ, Baker RT, Harris MJ, Parish CR (1999)
Cloning of mammalian heparanase, an important enzyme in tumour invasion and metastasis. Nature Med 5: 803-9.

Parish CR, Freeman C, Brown KJ, Francis D, Cowden WB (1999).
Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity. Cancer Res 59: 3433-41.

Rees D, Sloane T, Jessup W, Dean RT, Kritharides L (1999)
Apolipoprotein A-I stimulates secretion of apolipoprotein E by foam cell macrophages. J Biol Chem 274: 27925-33.

Santiago FS, Lowe HC, Kavurma MM, Chesterman CN, Atkins DG, Khachigian LM (1999)
Novel DNA enzyme targeting NGFI-A mRNA inhibits vascular smooth muscle proliferation and regrowth after injury. Nature Med. 11: 1264-9.

Buckley MF, James JW, Brown D, Whyte GS, Dean MG, Chesterman CN, Donald JA (2000).
A novel approach to the assessment of variations in the human platelet count. Thromb and Haemostasis. 83: 480-4.

Lay AJ, Jiang X-M, Kisker O, Flynn E, Underwood A, Condron R, Hogg PJ (2000)
Phosphoglycerate kinase acts in tumor angiogenesis as a disulfide reductase. Nature. 408: 869-73.

Baoutina A, Dean RT, Jessup W. (2001)
Trans-plasma membrane electron transport induces macrophage-mediated low density lipoprotein oxidation. FASEB J. 15: 1580-2.

Gardiner EE, De Luca M, McNally T, Michelson AD, Andrews RK, Berndt MC (2001)
Regulation of ligand binding to the neutrophil P-selectin receptor PSGL-1, by neutrophil elastase and cathepsin G. Blood. 98: 1440-7.

Garner B., Merry A.H., Royle L., Harvey D.J., Rudd. P.M. Thillet J. (2001)
Structural elucidation of the N- and O-glycans of human apolipoprotein(a). Role of O-glycans in conferring protease resistance. J Biol Chem. 276: 22200-8.

Lowe HC, Fahmy RG, Kavurma MM, Baker A, Chesterman CN, Khachigian LM (2001)
Catalytic oligodeoxynucleotides define a critical regulatory role for early growth response factor-1 in the porcine coronary artery model of in-stent restenosis. Circ Res. 89:670-7.

Manderson AP, Pickering MC, Botto M, Walport MJ and Parish CR (2001)
Continual low-level activation of the classical complement pathway. J Exp Med. 194: 745-56.

Tait AS, Cranmer SL, Jackson SP, Dawes IW, Chong BH (2001)
Phenotype changes resulting in high-affinity binding of von Willebrand factor to recombinant glycoprotein Ib-IX: analysis of the platelet-type von Willebrand disease mutations. Blood. 98: 1812-8.

Thomas SR, Salahifar H, Mashima R, Hunt NH, Richardson D, Stocker R (2001)
Antioxidants inhibit indoleamine 2,3-dioxygenase in interferon-gamma-activated human macrophages. Post-translational regulation by pyrrolidine dithiocarbamate. J Immunol. 166: 6332-40.

Xie L, Chesterman, CN, Hogg PJ (2001)
Control of von Willebrand factor multimer size by thrombospondin-1. J Exp Med. 193: 1341-9.

Yap S, Boers GH, Wilcken B, Wilcken DE, Brenton DP, Lee PJ, Walter JH, Howard PM, Naughten ER. (2001)
Vascular outcome in patients with homocystinuria due to cystathionine beta-synthase deficiency treated chronically: a multicenter observational study. Arterioscler Thromb Vasc Biol. 21: 2080-5.

Andrews RK, Suzuki-Inoue K, Shen Y, Tulasne D, Watson SP, Berndt MC (2002)
Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI. Blood. 99: 4219-21.

Gaustadnes M, Wilcken B, Oliveriusova J, McGill J, Fletcher J, Kraus JP, Wilcken DE. (2002)<
The molecular basis of cystathionine beta-synthase deficiency in Australian patients: genotype-phenotype correlations and response to treatment. Hum Mutat. 20: 117-26.

Matthias LJ, Yam PTW, Jiang X-M, Vandegraaff N, Li P, Poumbourios P, Donoghue N, Hogg PJ (2002)
Disulfide exchange in domain 2 of CD4 is required for entry of the Human Immunodeficiency Virus Type 1. Nature Immunol. 3: 727-32.

Rafty LA, Santiago FS, Khachigian LM. (2002)
NF1/X represses PDGF A-chain transcription by interacting with Sp1 and antagonizing Sp1 occupancy of the promoter. EMBO Journal. 21: 334-43.

Upston JM, Niu X, Brown AJ, Mashima R, Wang H, Senthilmohan R, Kettle AJ, Dean RT, and Stocker R. (2002)
Disease stage-dependent accumulation of lipid and protein oxidation products in human atherosclerosis. Am J Pathol. 160:701-10.

Burkhart CA, Cheng A, Madafiglio J, Kavallaris M, Mili M, Marshall GM, Weiss WA, Khachigian LM, Norris MD, Haber M (2003).
In vivo administration of N-myc antisense oligonucleotides reduces tumorigenesis in a murine model of neuroblastoma. Journal of National Cancer Institute 95:1394-1403.

Chen G, Gharib TG, Wang H, Huang C-C, Kuick R, Thomas DG, Shedden K.A, Misek DE, Taylor JMG, GiordanoTJ, Kardia SLR, Iannettoni MD, Yee J, Hogg PJ, Orringer MB, Hanash SM, Beer DG (2003).
Protein profiles associated with survival in lung adenocarcinoma. Proceedings of the National Academy of Sciences, USA 100, 13537-13542.

Don AS, Kisker O, Dilda P, Donoghue N, Zhao X, Decollogne S, Creighton B, Flynn E, Folkman J, Hogg PJ. (2003).
A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells. Cancer Cell 9:3, 497-509.

Eisbacher M, Holmes ML, Newton A., Hogg PJ, Khachigian LM Crossley M, Chong BH (2003).
Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA-binding. Molecular and Cellular Biology 23, 3427-3441.

Fahmy RG, Dass CR, Sun LQ, Chesterman CN, Khachigian LM (2003).
Zinc finger transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth. Nature Medicine 9:1026-1032.

Francis DJ, Parish CR, McGarry M, Santiago FS, Lowe HC, Brown KJ, Bingley J, Hayward IP, Cowden WB, Campbell JH, Campbell GR, Chesterman CN, Khachigian LM (2003).
Blockade of vascular smooth muscle cell proliferation and intimal thickening after balloon injury by the sulfated oligosaccharide PI-88: phosphomannopentaose sulfate directly binds FGF-2, blocks cellular signaling and inhibits proliferation. Circulation Research 92:E70-77.

Gaus K, Gratton E, Kable EPW, Jones AS, Gelissen I, Kritharides L, Jessup W (Dec 23, 2003).
Visualizing lipid structure and raft domains in living cells with 2-photon microscopy. Proc Natl Acad Sci USA, 100, 15554-9.

Gaus K. Kritharides L, Schmitz G, Boettcher A, Drobnik W, Langmann T, Quinn CM, Death A, Dean RT, Jessup W (published on-line 20th January 2004).
Apolipoprotein A-1 interaction with plasma membrane lipid rafts control cholesterol export from macrophages. FASEB J.

Lau A, Leichtweis SB, Hume P, Mashima R, Hou JY, Chaufour X, Wilkinson B, Hunt NH, Celermajer DS, Stocker R (2003).
Probucol promotes functional re-endothelialzation in balloon-injured rabbit aortas. Circulation 107:2031-2036.

Pimanda JE, Maekawa A, Wind T, Paxton J, Chesterman CN, Hogg PJ (2003).
Congenital thrombotic thrombocytopenic purpura in association with a mutation in the second CUB domain of ADAMTS13. Blood 103, 627-629.

Pimanda JE, Lowe HC, Hogg PJ, Chesterman CN, Khachigian LM (2003).
Novel and emerging therapies in cardiology and haematology. Current Drug Targets in Cardiovascular and Haematological Disorders 3, 101-123.