Research
CVR is multidisciplinary centre with laboratories located at UNSW, South Eastern Area Laboratory Services and Department of Cardiovascular Medicine at the Prince of Wales Hospital, Sydney, the Department of Medicine at St George Hospital, Sydney, the Division of Immunology and Cell Biology, the John Curtin School of Medical Research, ANU, Department of Pathology at University of Sydney, and the Department of Biochemistry at La Trobe University. The interaction between groups is reinforced by NHMRC Program Grants.
At The University of New South Wales |
 | |
Transcription & Gene Targeting
Group Leader: Prof Levon Khachigian (Director, Centre for Vascular Research)
 Cardiovascular disease and cancer remain the most important causes of morbidity and mortality. Our work has increased our understanding of the fundamental transcriptional mechanisms that lead to the inducible expression of key regulatory genes in vascular cells. We have pioneered the development of novel strategies targeting “master switch regulators” in a variety of vascular disorders. more»
| Macrophage Biology
Group Leaders: Prof Wendy Jessup (Deputy Director, Operations) and Prof Len Kritharides
  Our major research objective is to develop our knowledge of the biology of the macrophage, especially the macrophage foam cell in atherosclerosis. more»
|
| |
Cellular Membrane Biology Lab
Group Leader: A/Prof Katharina Gaus
 Our research aims to identify the principles that govern the organisation of lipids and proteins within the plasma membrane and thus define the mechanism of signal transduction processes. The overriding quest is to determine how specialised membrane domains organise signalling pathways. more»
| Complex Systems in Biology
Group Leader: A/Prof Miles Davenport
 Although many acute infectious diseases are now effectively controlled by vaccination, we currently lack vaccines for many chronic infectious agents. The Complex Systems in Biology group aims to understand the basic dynamics and pathogenesis of these infections, how the immune system interacts with them, and ultimately how we can control them. more»
|
| |
Redox Cell Signalling
Group Leader: Dr Shane Thomas
 The Redox Cell Signalling Laboratory focuses on two major research areas:
1. Identification of the redox reactions and cell signaling pathways important for endothelial dysfunction during vascular disease; 2. Roles and Regulation of Indoleamine 2, 3-Dioxygenase. more»
| Platelet and Megakaryocyte Group
Group Leader: Prof Beng Chong
 The focus of the research is megakaryocyte / platelet pathobiology. It can be broadly divided into two areas: (1) transcription regulation of megakaryopoiesis, and (2) platelet pathobiology. more»
|
| |
Former Director
Prof Colin Chesterman AO
 Colin was Foundation Director of the CVR for 16 years until 2008. He is Scientia Professor in the School of Medical Sciences and the Prince of Wales Clinical School, UNSW. His research focused on occlusive vascular disease including fibrinolysis, the characterisation & function of platelet granules, particularly PDGF, and aspects of the antiphospholid syndrome and vWF multimerisation. He is a Past-President of the Australian Vascular Biology Society, member of the Senior Advisory Council of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis (ISTH), and was President of the XXth Congress of the ISTH in Sydney in 2005.
| |
| |
At John Curtin School of Medical Research | At Sydney University |
| |
Cancer & Vascular Biology
Group Leader: Prof Chris Parish
 The major research interest of the Cancer and Vascular Biology Group is the molecular basis of cell adhesion, cell migration and cell invasion, with a particular emphasis on the immune system, tumour metastasis and the growth of new blood vessels (angiogenesis). more»
| Vascular Redox Processes
Group Leader: Prof Roland Stocker
 Our research aims to understanding how redox processes contribute to atherosclerosis, related disorders and diabetes; and how this can be exploited to develop novel therapeutics. more»
|
| |
At La Trobe University | At SEALS |
| |
Molecular Immunology and Cancer
Group Leader: Dr Mark Hulett
 The ability of malignant tumour cells to escape from primary tumour sites and spread through the circulation to other sites in the body (metastasis) is what makes cancer such a deadly disease. Understanding the molecular basis of cell invasion and angiogenesis is vital to develop strategies to combat cancer spread and inflammatory disease. more»
| Molecular Genetics Group
Group Leader: Dr Michael Buckley
 The aim of the first project is to identify genes that regulate the process of thrombopoiesis. We have shown that 85% of the normal variation in platelet count in humans is genetically determined. more»
|